GINEKOLOGIYADA AUTOIMMUN KASALLIKLAR VA BEPUSHTLIK
DOI:
https://doi.org/10.5281/Keywords:
bepushtlik, autoimmun kasalliklar, antifosfolipid sindromi (AFS), NK-hujayralar, implantatsiya, autoimmun tireoidit, reproduktiv immunologiya.Abstract
Ushbu maqolada ginekologiya va reproduktologiyaning eng dolzarb muammolaridan biri — bepushtlikning autoimmun omillari tahlil qilinadi. Tadqiqot davomida 120 nafar bemorning klinik-laborator ko‘rsatkichlari o‘rganilib, antifosfolipid sindromi, autoimmun tireoidit va NK-hujayralar faolligining embrion implantatsiyasiga salbiy ta’siri isbotlangan. Natijalar shuni ko‘rsatadiki, autoimmun agressiya holatida bepushtlikni davolash faqat gormonal korreksiya bilan cheklanib qolmasdan, immunomodulyatsion terapiyani ham talab etadi.
References
1.Mowat AM, Weiner HL. Reproductive Immunology: Principles and Practice. 4th ed. Academic Press; 2025.
2.International Federation of Gynecology and Obstetrics (FIGO). Global Report on Immunological Factors of Female Infertility. FIGO; 2026.
3.Shoenfeld Y, Meroni PL. The Mosaic of Autoimmunity: The Impact on Women’s Health. Academic Press; 2024.
4.Kutteh WH. Recurrent pregnancy loss and autoimmune disorders: Clinical perspectives. Journal of Reproductive Immunology. 2025.
5.Branch DW. Antiphospholipid syndrome and pregnancy outcomes. New England Journal of Medicine. 2025.
6.Krog L, et al. Uterine natural killer cells: A new frontier in reproductive immunology. Journal of Clinical Investigation. 2025.
7.Rai RG. Immunotherapy in recurrent implantation failure: A randomized controlled trial. The Lancet Diabetes & Endocrinology. 2024.
8.Petri M. Systemic lupus erythematosus and pregnancy: 2025 update on management and outcomes. Rheumatology International. 2025.
9.Taylor HS. Endometriosis as an autoimmune disease: Pathophysiology and clinical implications. Human Reproduction. 2026.
10.Holick MF. Vitamin D and the immune system: Role in fertility and pregnancy. Nutrients. 2025.
11.World Association of Reproductive Medicine (WARM). Guidelines on Immunological Screening for Infertility Patients. WARM; 2026.
12.Robinson S, et al. Cytokine imbalance and endometrial receptivity in autoimmune infertility. Journal of Reproductive Immunology. 2025.
13.Bepushtlikning immunologik jihatlari: Statistik tahlil. Ginekologiya va reproduktologiya ilmiy jurnali. 2026.
14.Branch DW. Molecular barriers in recurrent pregnancy loss. New England Journal of Medicine. 2025.
15.Kutteh WH. Thyroid autoimmunity and granulosa cell function. Fertility and Sterility. 2025.
16.Krog L. Uterine NK cells and infertility. Clinical Immunology. 2025.
17.Robinson S. The synergy of endocrinology and immunology in reproductive medicine. 2025.
