HEMORRHAGIC PATHOLOGY, PHYSIOLOGY, AND DIAGNOSTICS
DOI:
https://doi.org/10.5281/zenodo.18796130Keywords:
Hemorrhagic disorders, hemostasis, coagulation factors, platelet dysfunction, pathology.Abstract
Hemorrhagic disorders are characterized by abnormal bleeding resulting from disturbances in vascular structure, platelet function, coagulation factors, or fibrinolytic activity. Examines the pathology, physiological mechanisms, and diagnostic approaches related to hemorrhagic conditions. The pathological classification includes vascular abnormalities, platelet disorders, coagulation factor deficiencies, and mixed systemic conditions such as disseminated intravascular coagulation. The physiological basis of bleeding is explained through the stages of hemostasis, including primary and secondary clot formation, regulatory anticoagulant systems, and fibrinolysis.
References
Hoffman, M., & Monroe, D. M. (2018). A cell-based model of hemostasis. Thrombosis and Haemostasis, 85(6), 958–965.
Kumar, V., Abbas, A. K., & Aster, J. C. (2021). Robbins & Cotran Pathologic Basis of Disease (10th ed.). Elsevier.
McPherson, R. A., & Pincus, M. R. (2022). Henry’s Clinical Diagnosis and Management by Laboratory Methods (24th ed.). Elsevier.
Jameson, J. L., Fauci, A. S., Kasper, D. L., Hauser, S. L., & Loscalzo, J. (2022). Harrison’s Principles of Internal Medicine (21st ed.). McGraw-Hill Education.
Kessler, C. M., & Friedman, K. D. (2020). Hemophilia and other inherited bleeding disorders. Hematology/Oncology Clinics of North America, 34(6), 1011–1028.
Sadler, J. E. (2020). Von Willebrand disease: Advances in pathophysiology and treatment. Blood, 136(5), 567–575.
Levi, M., & Scully, M. (2018). How I treat disseminated intravascular coagulation. Blood, 131(8), 845–854.
Tripodi, A., & Mannucci, P. M. (2020). The coagulopathy of chronic liver disease. New England Journal of Medicine, 365(2), 147–156.
Lippi, G., & Favaloro, E. J. (2021). Global hemostasis assays: Thromboelastography and beyond. Seminars in Thrombosis and Hemostasis, 47(4), 381–390.