ROLE OF VAGINAL MICROBIOTA IN THE PATHOGENESIS OF PRETERM BIRTH

Authors

  • Sarvinoz Baxramova Andijan branch of Kokand University 3rd year student of the medical field

DOI:

https://doi.org/10.5281/zenodo.18628512

Keywords:

Preterm birth, vaginal microbiota, dysbiosis, Lactobacillus, intrauterine infection, inflammation, cytokines, cervical remodeling, neonatal outcomes.

Abstract

Preterm birth remains one of the leading causes of neonatal morbidity and mortality worldwide. Despite advances in obstetric care, the underlying mechanisms contributing to spontaneous preterm labor are not fully understood. Increasing evidence suggests that alterations in the vaginal microbiota play a critical role in the pathogenesis of preterm birth.

References

Callahan, B. J., DiGiulio, D. B., Goltsman, D. S. A., Sun, C. L., Costello, E. K., Jeganathan, P., … Relman, D. A. (2017). Replication and refinement of a vaginal microbial signature of preterm birth in two racially distinct cohorts of US women. Proceedings of the National Academy of Sciences of the United States of America, 114(37), 9966–9971.

DiGiulio, D. B., Callahan, B. J., McMurdie, P. J., Costello, E. K., Lyell, D. J., Robaczewska, A., … Relman, D. A. (2015). Temporal and spatial variation of the human microbiota during pregnancy. Proceedings of the National Academy of Sciences, 112(35), 11060–11065.

Fettweis, J. M., Serrano, M. G., Brooks, J. P., Edwards, D. J., Girerd, P. H., Parikh, H. I., … Jefferson, K. K. (2019). The vaginal microbiome and preterm birth. Nature Medicine, 25(6), 1012–1021.

Goldenberg, R. L., Culhane, J. F., Iams, J. D., & Romero, R. (2008). Epidemiology and causes of preterm birth. The Lancet, 371(9606), 75–84.

Leitich, H., & Kiss, H. (2007). Asymptomatic bacterial vaginosis and intermediate flora as risk factors for adverse pregnancy outcome. American Journal of Obstetrics and Gynecology, 196(2), 95–101.

Ravel, J., Gajer, P., Abdo, Z., Schneider, G. M., Koenig, S. S., McCulle, S. L., … Forney, L. J. (2011). Vaginal microbiome of reproductive-age women. Proceedings of the National Academy of Sciences, 108(Suppl 1), 4680–4687.

Romero, R., Dey, S. K., & Fisher, S. J. (2014). Preterm labor: One syndrome, many causes. Science, 345(6198), 760–765.

Romero, R., Miranda, J., Chaiworapongsa, T., Chaemsaithong, P., Gotsch, F., Dong, Z., … Yoon, B. H. (2014). A novel molecular microbiologic technique for the diagnosis of microbial invasion of the amniotic cavity and intra-amniotic inflammation in preterm labor. American Journal of Obstetrics and Gynecology, 210(2), 135.e1–135.e18.

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Published

2026-02-12

How to Cite

Baxramova, S. (2026). ROLE OF VAGINAL MICROBIOTA IN THE PATHOGENESIS OF PRETERM BIRTH. Academic Research in Modern Science, 5(6), 46-51. https://doi.org/10.5281/zenodo.18628512