“NON-OPIOID STRATEGIES FOR POSTOPERATIVE PAIN RELIEF IN NEONATES WITH CONGENITAL ANOMALIES”
DOI:
https://doi.org/10.5281/zenodo.17092060Keywords:
non-opioid analgesia, neonates, congenital anomalies, ibuprofen, paracetamol, DAN, COMFORTneo, postoperative painAbstract
The study investigated the effectiveness of non-opioid analgesics in 62 newborns undergoing surgery for congenital anomalies. Pain assessment was performed using DAN and COMFORTneo scales. Ibuprofen (IV infusion, 5–10 mg/kg/day) and paracetamol (rectal, 15 mg/kg/6h) were compared with standard morphine therapy (0.05–0.1 mg/kg). Non-opioid regimens significantly reduced behavioral pain scores, stabilized hemodynamic parameters, and lowered cortisol levels. Opioid requirement was reduced by 45–50%, while the incidence of adverse reactions was minimal. Non-opioid therapy demonstrated superior safety, clinical effectiveness, and economic efficiency, supporting its integration into neonatal postoperative pain management protocols.
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