FERROPTOSIS: A NOVEL MECHANISM OF CELL DEATH AND ITS THERAPEUTIC POTENTIAL
DOI:
https://doi.org/10.5281/Keywords:
Ferroptosis; Iron metabolism; Lipid peroxidation; GPX4; Oxidative stress; Biochemistry; Molecular pharmacology.Abstract
Ferroptosis is a recently recognized form of regulated cell death characterized by iron-dependent lipid peroxidation and irreversible damage to cellular membranes. Unlike apoptosis, necrosis, or autophagy, ferroptosis is driven primarily by oxidative stress, intracellular iron accumulation, and the depletion of glutathione-dependent antioxidant defenses. Since its formal description in 2012, ferroptosis has become one of the fastest-growing research areas in biochemistry, molecular biology, and pharmacology due to its significant role in the pathogenesis of numerous human diseases.
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