AGE-RELATED MORPHOLOGICAL CHANGES AND CLINICAL DYNAMICS OF POST-TRAUMATIC NASAL SEPTUM DEVIATION-ASSOCIATED NASAL POLYPOSIS
DOI:
https://doi.org/10.5281/zenodo.17008015Abstract
Nasal polyposis (NP) is one of the most common manifestations of chronic rhinosinusitis, characterized by persistent inflammation and tissue remodeling within the sinonasal mucosa. Post-traumatic nasal septum deviation and related structural damage often accelerate the development of nasal polyposis through long-standing inflammatory processes. Age-related morphological variations of the nasal mucosa are of particular interest, as they may influence both histopathological features and the clinical course of the disease. Understanding these differences is essential for optimizing age-specific therapeutic strategies.
References
Fokkens WJ, Lund VJ, Hopkins C, et al. European Position Paper on Rhinosinusitis and Nasal Polyps 2020. Rhinology. 2020;58(S29):1–464.
Schleimer RP. Immunopathogenesis of chronic rhinosinusitis and nasal polyposis. Annu Rev Pathol. 2017;12:331–357.
Van Bruaene N, Perez-Novo CA, Basinski TM, et al. T-cell regulation in chronic paranasal sinus disease. J Allergy Clin Immunol. 2008;121(6):1435–1441.
Bachert C, Zhang N, Holtappels G, De Lobel L, van Cauwenberge P. Nasal polyposis: Molecular and cellular mechanisms. Allergy. 2007;62(4):331–341.
Soyka MB, Wawrzyniak P, Eiwegger T, et al. Defective epithelial barrier in chronic rhinosinusitis. J Allergy Clin Immunol. 2012;130(5):1087–1096.
