ASSESSMENT OF INDIVIDUAL TYPOLOGICAL CHARACTERISTICS OF ANIMALS IN THE EXPERIMENTAL MODEL OF DIABETES

Authors

  • A.A. Mavlonov Bukhara State Medical Institute, Tashkent State Dental Institute
  • S.A. Saidov Bukhara State Medical Institute, Tashkent State Dental Institute
  • J.T. Bafaev Bukhara State Medical Institute, Tashkent State Dental Institute

DOI:

https://doi.org/10.5281/zenodo.8013673

Abstract

An individual-typological approach to the body's response to the disease and its complications can facilitate many issues of pathophysiology, pathochemistry and pharmacokinetics, especially in diabetes mellitus. There are quite a few studies around the terrible complications of this disease, associated with impaired microcirculation, often leading to disability and death. Among the pathologies that lead to serious, irreversible microcirculation dysfunctions, the main role is given to diabetes mellitus, which is the most widespread condition studied.

References

Allen J. Photoplethysmography and its application in clinical physiological measurement. Physiol Meas. 2007;28(3):R1–39.

Antia B.S. Hypoglyacaemic effect of aqueous leaf extract of Persea Americana (Mill,) on alloxan induced diabetic rats / B.S. Antia, J.E. Okokon, P.A. Okon // Indian J. pharmacol. 2005. V. 37. P. 325-326.

Anti-diabetic and antioxidant effects of Zingiber Officinale on alloxan-induced and insulin-resistant diabetic male rats / B.O. Iranloye [et. al] // J. Physiol. Sci. – 2011. – V. 26. – P. 89-96.

Antihyperglycemic and antihyperlipidemic activity of plectranthus amboinicus on normal and alloxaninduced diabetic rats /A.H. Viswanathaswamy [et. al] // Ind. J. Pharm. Sci. – 2011. – V. 73. – P. 139-45.

Beretta, A. Campanha de prevencao e diagnostico do diabetes realizada pela UNIARARAS e prefeitura municipal nacidade de Araras / A. Beretta // Laes and Haes. – 2001. V. 22(131). P. 188-200.

Das, J. Taurine exerts hypoglycemic effect in alloxan-induced diabetic rats, improves insulin-mediated glucose transport signaling pathway in heart and ameliorates cardiac oxidative stress and apoptosis / J. Das, V. Vasan, P.C. Sil // Toxicol. Appl Pharmacol. – 2012. – V. 258. – P. 296-308.

Effect of streptozotocin on the ultrastructure of rat pancreatic islets / M.D. Mythili [et al.] // Microsc Res Tech. 2004. V. 63. P. 274-281.

Elsner M. Relative importance of cellular uptake and reactive oxygen species for the toxicity of alloxan and dialuric acid to insulinproducing cells / M. Elsner, E. Gurgul-Convey, S. Lenzen // Free Radic Biol Med. 2006. V. 41. P. 825-834.

Etuk E.U. Animals models for studying diabetes mellitus / E.U. Etuk // Agric. Biol. J.N. am. 2010. 1 (2). P. 130-134.

Experimental model of induction of diabetes mellitus in rats / C.S. Macedo [et al.] // Plastic surgery, laboratory of plastic surgery: Sao Paulo - Paulista School of Medicine. 2005. P. 2-5.

Importance of the GLUT2 glucose transporter for pancreatic beta cell toxicity of alloxan / M. Elsner [et al.] // Diabetologia. 2002. V.45. P. 1542-1549.

Induction of type 1 diabetes rnellitus in’ laboratory rats by use of attoxan route of administration, pitfalls, and insulin treatment / I.F. Federiuk [et al.] // Comprehensive Medicine. 2004. V. 54. P. 252-257.

Gurfinkel Yu. Computer capillaroscopy as a channel of local visualization, noninvasive diagnostics, and screening of substances in circulating blood. Proc. SPIE;

Lenzen, S. The mechanisms of alloxan and streptozotocin induced diabetes / S. Lenzen // Diabetologia. 2008. – V. 51. P. 216-226.

Managing diabetes with integrated teams: maximizing your efforts with limited time / D.F. Kruger [et. al] // Postgrad Med. –2012. – V. 124. – P. 64-76.

Managing type 2 diabetes: going beyond glycemic control /M.W. Stolar [et. al] // J. Manag Care Pharm. – 2008. – V. 14. – P. 2-19.

Masiello, P. Animal models of type11 diabetes with reduced pancreatic b-cell mass / P. Masiello // The international Journal of Biochemistry and Ceil Brology. 2006. V. 38. P. 873-893.

Malaisse W.J. [et al.] Pancreatic uptake of alloxan // Int J. Mol Med. [2-(14) C] 2001. V. 7. P. 311-315.

Rees, D.A. Animal models of diabetes mellitus / D.A. Rees, J.C. Alcolado // Diabetic Medicine. – 2005. – V. 22. P. 359-370.

Roustit M., Cracowski J.L. Non-invasive assessment of skin microvascular function in humans: an insight into methods. Microcirculation. 2012;19(1):47–64. doi: 10.1111/j.1549-8719.2011.00129.x.

Saratov Fall Meeting 2000: Optical Technologies in Biophysics and Medicine II (May 4, 2001). p. 467. doi: 10.1117/12.431560.

Szkudelski, T. The mechanism of alloxan and streptozotocin action B ceils of the rat pancreas / T. Szkudelski // Physiology. Res. 2001. V. 50. – P. 536-546.

The use of animal models in the study of diabetes mellitus / A. Chatzigeorgiou [et. al] // In Vivo. – 2009. – V. 23. – P.245-58.

Wright CI, Kroner CI, Draijer R. Non-invasive methods and stimuli for evaluating the skin's microcirculation. J Pharmacol Toxicol Methods. 006;54(1):1–25. doi: 10.1016/j. vascn.2005.09.004.

Балаболкин М.И. Диабетология: монография. – М.: Медицина, 2000. – 672 с.

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Published

2023-06-06

How to Cite

Mavlonov, A., Saidov, S., & Bafaev, J. (2023). ASSESSMENT OF INDIVIDUAL TYPOLOGICAL CHARACTERISTICS OF ANIMALS IN THE EXPERIMENTAL MODEL OF DIABETES. Development of Pedagogical Technologies in Modern Sciences, 2(6), 18-22. https://doi.org/10.5281/zenodo.8013673