TECHNOLOGY FOR THE SYNTHESIS OF VINYL DERIVATIVES OF AROMATIC AMINES
DOI:
https://doi.org/10.5281/zenodo.18387343Keywords:
aromatic amines, vinylation, N-vinyl derivatives, catalysis, Heck reaction, photocatalysis, organic synthesis, selectivityAbstract
This article examines modern technologies for the synthesis of vinyl derivatives of aromatic amines, with particular emphasis on reaction mechanisms, catalytic systems, and the influence of key process parameters. The role of metal catalysts, including palladium, nickel, and copper, in enhancing vinylation efficiency and selectivity is analyzed. Special attention is given to N-vinylation reactions as technologically favorable and environmentally safer routes. Contemporary approaches based on photocatalysis and green chemistry principles are discussed alongside their industrial applicability. The advantages of highly selective vinyl derivatives, their application areas, and prospects for large-scale production are highlighted. The study contributes to the development of sustainable and efficient synthetic pathways in the chemistry of aromatic amines.
References
Methods for the Synthesis of O-, S- and N-Vinyl Derivatives. Russian Chemical Reviews, vol. 86, no. 3, 2017, pp. 219–256.
Abdugʻaniyev, S. A. Chemistry of Amines and Heterofunctional Compounds. Tashkent: Universitet Publishing House, 2020.
Carral-Menoyo, A., et al. “Palladium-Catalysed Heck-Type Alkenylation Reactions: Recent Developments and Applications.” Catalysis Science & Technology, vol. 10, no. 14, 2020, pp. 4477–4492.
Noble, A., and D. W. C. MacMillan. “Photoredox α-Vinylation of α-Amino Acids and N-Aryl Amines.” Journal of the American Chemical Society, vol. 136, no. 33, 2014, pp. 11602–11605.
Omonboyeva, M. Sh. Fundamentals of Organic Synthesis and Modern Directions of Catalysis. Tashkent: Fan va Texnologiya Publishing House, 2021.
Oxtoby, L. J., et al. “Recent Advances in Reductive Heck Coupling of Alkenes.” ACS Catalysis, vol. 9, no. 9, 2019, pp. 7925–7940.
Rodygin, K. S., et al. “Practical N-Vinylation of Secondary Amines with Calcium Carbide.” Molecules, vol. 23, no. 12, 2018, pp. 1–14.
Sodiqov, I. S., and R. M. Abdurahmonov. Fundamentals of Organic Chemistry. Tashkent: O‘qituvchi Publishing House, 2016.
Xu, J., et al. “Room-Temperature Palladium(II)-Catalyzed N-Vinylation of Amines.” Tetrahedron Letters, vol. 51, no. 47, 2010, pp. 6180–6183.
Xudayberganov, J. T., and O. X. Omonov. Organic Chemistry: Theoretical Foundations and Practice. Tashkent: Publishing House of the Academy of Sciences of Uzbekistan, 2019