BYPASSING THE HLA SYSTEM IN ORGAN TRANSPLANTATION: OPPORTUNITIES TO ACHIEVE UNIVERSAL COMPATIBILITY VIA FULL SUPPRESSION AND ARTIFICIAL IMMUNOBIOCODING
DOI:
https://doi.org/10.5281/zenodo.17119046Keywords:
HLA, organ transplantation, CRISPR/Cas9, universal donor, immunobiocoding, iPSC, immune evasion, NK cells, immunosuppression.Abstract
This study explores innovative strategies to overcome HLA incompatibility in organ transplantation, a major cause of graft rejection. Two promising approaches are highlighted: CRISPR/Cas9-mediated deletion of HLA genes and artificial immunobiocoding to create universal donor cells. Gene editing to suppress classical HLA expression, while preserving non-classical molecules like HLA-E, has shown reduced immune recognition in preclinical models. Additionally, the expression of immunomodulatory molecules such as PD-L1 and CD47 further enhances immune evasion. Ongoing clinical efforts, including iPSC banks and universal stem cell lines, indicate substantial progress toward safer, more accessible transplantation without long-term immunosuppression.
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