THE ASSOCIATION BETWEEN CLINICAL AND GENETIC MARKERS WITH RENAL AND HEPATOBILIARY DISORDERS IN GOUT PATIENTS
DOI:
https://doi.org/10.5281/zenodo.17230831Keywords:
gout, renal impairment, hepatobiliary disorders, clinical markers, genetic predisposition, urate metabolism.Abstract
Gout is a common metabolic disorder characterized by disturbances in purine metabolism and chronic hyperuricemia, which not only manifests as recurrent arthritis but also contributes to systemic organ involvement. Among the most clinically significant complications are renal and hepatobiliary disorders, which substantially affect patient prognosis and quality of life. The present study aimed to investigate the association between clinical parameters, biochemical indices, and genetic markers with renal and hepatic involvement in patients with gout. Analysis revealed that renal impairment was frequently linked with early markers of urate nephropathy, such as reduced glomerular filtration rate and microalbuminuria, while hepatobiliary dysfunction was associated with altered lipid metabolism and elevated hepatic enzyme levels. Furthermore, genetic variations in genes related to purine metabolism and urate transport demonstrated a strong correlation with the severity and progression of these complications. These findings suggest that combined evaluation of clinical and genetic markers may provide valuable prognostic information and serve as a basis for personalized therapeutic strategies in gout patients with renal and hepatobiliary involvement.
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