Перейти к главному меню навигации Перейти к основному контенту Перейти к нижнему колонтитулу сайта

Том 3 № 11 (2024)
Инновационные исследования в науке

Статьи

GALLIUM-68 RADIOPHARMACY IN NUCLEAR MEDICINE

Опубликован 2024-11-29

  • Mehmonov G.
    • ,
  • Khujaev S.
    • ,
  • S.Kh.Egamediev

Mehmonov G.
Institute of Nuclear Physics, Uzbekistan Academy of Science, Tashkent, Uzbekistan

Khujaev S.
Institute of Nuclear Physics, Uzbekistan Academy of Science, Tashkent, Uzbekistan

S.Kh.Egamediev
Institute of Nuclear Physics, Uzbekistan Academy of Science, Tashkent, Uzbekistan

Аннотация

Gallium-68 (68Ga) is a positron-emitting radionuclide that has gained prominence in nuclear medicine due to its exceptional versatility in diagnostic imaging and theranostics. Its unique physical and chemical properties make it ideal for PET imaging, especially in cancer diagnostics. This article provides an overview of 68Ga's role in radiopharmacy, explores its production methods and highlights its theranostic applications.

Ключевые слова

Gallium-68, Nuclear medicine, Cyclotron production, Generator production Ge68/Ga68, Cancer diagnostics, Theranostics.

PDF

Библиографические ссылки

  1. I. I. P. P. Ltd., “Nuclear medicine,” IP Innov. Publ. Pvt Ltd, Jan. 2019, Accessed: Apr. 19, 2024. [Online]. Available: https://www.academia.edu/43837833/Nuclear_medicine
  2. F. Rösch, “68Ge/68Ga Generators and 68Ga Radiopharmaceutical Chemistry on Their Way into a New Century,” J. Postgrad. Med. Educ. Res., vol. 47, no. 1, pp. 18–25, Mar. 2013, doi: 10.5005/JP-JOURNALS-10028-1052.
  3. “NuDat 3.” Accessed: Jun. 23, 2024. [Online]. Available: https://www.nndc.bnl.gov/nudat3/
  4. M. A. Synowiecki, L. R. Perk, and J. F. W. Nijsen, “Production of novel diagnostic radionuclides in small medical cyclotrons,” EJNMMI Radiopharmacy and Chemistry, vol. 3, no. 1. SpringerOpen, Dec. 01, 2018. doi: 10.1186/s41181-018-0038-z.
  5. P. J. Pao, D. J. Silvester, and S. L. Waters, “A new method for the preparation of68Ga-generators following proton bombardment of gallium oxide targets,” J. Radioanal. Chem., vol. 64, no. 1–2, pp. 267–272, Mar. 1981, doi: 10.1007/BF02518357/METRICS.
  6. K. Kumar, “The Current Status of the Production and Supply of Gallium-68,” Cancer Biother. Radiopharm., vol. 35, no. 3, 2020, doi: 10.1089/cbr.2019.3301.
  7. G. B. Saha, Fundamentals of Nuclear Pharmacy Seventh Edition. 2018.
  8. S. Riga et al., “Production of Ga-68 with a General Electric PETtrace cyclotron by liquid target,” Phys. Med., vol. 55, pp. 116–126, Nov. 2018, doi: 10.1016/J.EJMP.2018.10.018.
  9. M. Meisenheimer, Y. Saenko, E. Eppard, M. Meisenheimer, Y. Saenko, and E. Eppard, “Gallium-68: Radiolabeling of Radiopharmaceuticals for PET Imaging - A Lot to Consider,” Med. Isot., Dec. 2019, doi: 10.5772/INTECHOPEN.90615.
  10. IAEA, “Gallium-68 Cyclotron Production IAEA-TECDOC-1853,” Iaea-Tecdoc-1853, 1863.