HASHIMOTO TIREOIDITI VA AUTOIMMUN JARAYONLARINING MEXANIZMLARI
DOI:
https://doi.org/10.5281/zenodo.17907566Keywords:
Hashimoto tireoiditi, autoimmun tiroidit, T-limfotsitlar, B-limfotsitlar, sitokinlar, autoantitelolar, genetik predispozitsiya, immun patogenez, tiroid hujayralarining apoptozi, surunkali yallig‘lanish, klinik diagnostika, individual davolash.Abstract
Hashimoto tireoiditi - qalqonsimon bezning autoimmun yallig‘lanish bilan kechadigan surunkali kasalligi bo‘lib, limfotsitlar infiltratsiyasi va autoantitelolar ishlab chiqarilishi natijasida tiroid hujayralarining progresiv buzilishi bilan xarakterlanadi. Ushbu maqolada kasallikning molekulyar va immunologik mexanizmlari, shu jumladan T-limfotsitlar va B-limfotsitlar faoliyati, sitokin signallari va genetik predispozitsiya omillari tahlil qilinadi. Shuningdek, Hashimoto tireoiditida antitelolar, hujayra-apoptozi va endogen hamda eksogen atrof-muhit omillarining roliga e’tibor qaratiladi. Maqola autoimmun tiroiditlarning patogenezini chuqur tushunish, diagnostika strategiyalarini takomillashtirish hamda individual davolash yondashuvlarini rivojlantirish uchun ilmiy asos yaratishga qaratilgan.
References
Jameson, J. L., & De Groot, L. J. Endocrinology: Adult and Pediatric, 8th Edition. Philadelphia: Elsevier, 2017.
Weetman, A. P. Autoimmune Thyroid Disease: Pathogenesis and Clinical Management. London: Springer, 2015.
Brent, G. A. Clinical Practice. Autoimmune Thyroid Disease. New England Journal of Medicine Book Edition, 2012.
Melmed, S., Polonsky, K. S., Larsen, P. R., & Kronenberg, H. M. Williams Textbook of Endocrinology, 14th Edition. Philadelphia: Elsevier, 2020.
Rose, N. R., & Mackay, I. R. The Autoimmune Diseases, 6th Edition. London: Academic Press, 2019.
Vanderpump, M. P. The Epidemiology of Thyroid Disease. Oxford: Oxford University Press, 2011.
McLeod, D. S. A., & Cooper, D. S. The Thyroid: A Fundamental and Clinical Text, 11th Edition. Philadelphia: Lippincott Williams & Wilkins, 2020.
De Felice, M., & Di Lauro, R. Developmental and Molecular Biology of the Thyroid Gland. Berlin: Springer, 2014.
Pearce, E. N., & Farwell, A. P. Thyroid Disease: Mechanisms, Diagnosis and Therapy. Cambridge: Cambridge University Press, 2016.
Glick, S. M., & Kaplan, M. M. Immunology of the Endocrine System. New York: Marcel Dekker, 2008.
