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Vol. 4 No. 15 (2025)
Models and methods in modern science

Статьи

TIZIMLI QIZIL YUGURIKDA INTERFERON-STIMULLANGAN GENLAR MUTATSIYASI HAMDA ULARNING KLINIK-MOLEKULYAR GENETIK ASOSLARI.

Published 2025-11-24

  • Islomova Mohinur Tolib kizi

Islomova Mohinur Tolib kizi
Alfraganus University, Tashkent, Uzbekistan. Toshkent davlat tibbiyot universiteti Tashkent, Uzbekistan Farabi street 2

Abstract

So‘nggi yillarda tug‘ma va orttirilgan immunitetning molekulyar asoslarini chuqurroq o‘rganish natijasida ushbu interferonlarning autoimmun kasalliklardagi roli qayta ko‘rib chiqildi. Bugungi kunga kelib, interferon tomonidan tartibga solinadigan ko‘plab genlar — “interferon imzosi genlari” (IFN signature genes) aniqlangan. Ushbu genlarning ekspressiyasi tizimli qizil yugurik (TQY) bilan kasallangan bemorlarda sezilarli darajada ortgani aniqlangan, bu esa I tip va III tip interferonlarning TQY patogenezidagi muhim rolini ko‘rsatadi.

Keywords

Tizimli qizil yugurik, interferon, T-limfotsit yoki T-hujayra, avtoimmunitet, sitokinlar, anifrolumab, sifalimumab, rontalizumab.

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References

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